In situ multimodal transparent electrophysiological hydrogel for in vivo miniature two-photon neuroimaging and electrocorticogram analysis
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06.21/
2023
In situ multimodal transparent electrophysiological hydrogel for in vivo miniature two-photon neuroimaging and electrocorticogram analysis
Wei Wei, Mingming Hao, Kai Zhou, Yongfeng Wang, Qifeng Lu, Hui Zhang, Yue Wu, Ting Zhang, Yaobo Liu
Publication: Acta Biomaterialia
Read more: In situ multimodal transparent electrophysiological hydrogel for in vivo miniature two-photon neuroimaging and electrocorticogram analysis - ScienceDirect
Abstract
Hydrogels are widely used in nerve tissue repair and show good histocompatibility. There remain, how- ever, challenges with hydrogels for applications related to neural signal recording, which requires a tissue- like biomechanical property, high optical transmission, and low impedance. Here, we describe a transpar- ent hydrogel that is highly biocompatible and has a low Young’s modulus (0.15 MPa). Additionally, it functions well as an implantable electrode, as it conformably adheres to brain tissue, results in mini- mal inflammation and has a low impedance of 150 Ω at 1 kHz. Its high transmittance, corresponding to 93.35% at a wavelength of 300 nm to 1100 nm, supports its application in two-photon imaging. Con- sistent with these properties, this flexible multimodal transparent electrophysiological hydrogel (MTEHy) electrode was able to record neuronal Ca 2 + activity using miniature two-photon microscopy. It also used to monitor electrocorticogram (ECoG) activity in real time in freely moving mice. Moreover, its compat- ibility with magnetic resonance imaging (MRI), indicates that MTEHy is a new tool for studying activity in the cerebral cortex.
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