The brain is the most complex organ of an organism, and its structure and function have always been a hot topic in neuroscience research.Nerve cells are one of the basic structural and functional units of the nervous system. They have the functions of feeling stimulation and transmitting excitement. Each nerve cell is connected through synapses to transmit and process information. Neurons of different properties and functions in the brain form neural loops through various forms of complex connections, and different brain regions are in charge of different functions.Controlling body activity is one of the most important functions of the brain, which requires model animals to be able to image under free behavioral conditions.


Based on the advantages of long-wavelength excitation of two-photon microscopy, deeper penetration ability, low phototoxicity and photobleaching, long-term imaging, etc., it has been widely used in neuron imaging, dendritic spine imaging, neural network structure imaging, and Ca2+ imaging. The imaging quality of FIRM-TPM is comparable to that of large desktop two-photon microscopes.


This wearable two-photon microscope is an important tool for exploring the mysteries of the brain and studying the mechanisms of nervous system diseases. It provides an ideal tool for single-neuron imaging and neural network analysis of the deep brain regions of free-moving animals, and has shown excellent performance in neuroscience experiments.Edward Mosor, winner of the Nobel Prize in biology or Medicine (Edvard.I. Dr. Moser) called this microscope a “revolutionary” new tool in the field of neuroscience research, especially for the spatial positioning of the nervous system in the brain he studied, and believes that “in a few years, this new technology will dominate the neuroimaging of living animals, and the work is extremely important to the scientific community.”Professor Alcino J Silva of the University of California, Los Angeles, a famous American neuroscientist, wrote in his commentary, “By any standard, this microscope represents a major technological invention that will definitely change the way we observe cell and subcellular structures in free-moving animals.